We found that patients with high-LARS1 levels tended to have significantly higher tumor grades (P<0.001), while patients also appeared to have more advanced stages in high-LARS1 group, although without statistical significance (P=0.1) (Figures 5G–J), suggesting the potential relationship between LARS1 and the differentiation grade of HCC. Here, LARS1 is linked to hepatocellular carcinoma.