The balance between tumor cell apoptosis and survival depends on the activities of anti-apoptotic proteins Bcl-2, Wnt and NFκB signaling pathways, as well as the ratio between the activities of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt) signaling pathways. The gene discussed is NFKB1; the disease is neoplasm.