The IL-17 accumulated in TME can promote the generation of inducible-nitric-oxide-synthase (iNOS) in TAMSCs, upregulate the programmed cell death 1 ligand 1 (PD-L1) on the surface of TAMSCs, inhibit the normal function of T cells, and promote tumor immune escape (142). The gene discussed is CD274; the disease is neoplasm.