In addition, methyltransferase-like 3 (METTL3) is highly expressed in osteosarcoma cells (101, 102), and the N6-methyladenosine (m6A) modification it participates in can act on the methylation sites of TGF-β1 mRNA, thus affecting related signaling pathways (103, 104). This evidence concerns the gene METTL3 and osteosarcoma.