IQGAP1 and familial pancreatic carcinoma: The E3 ubiquitin ligase Mindbomb 1 (MIB1), previously found to be highly expressed in pancreatic cancer cells and associated with poor prognosis, has been shown to induce the degradation of the tumor suppressor ST7 through the ubiquitin-proteasome system, thereby increasing IQGAP1 expression and promoting pancreatic cancer migration and invasion (63).