AKT1 and glioma: miR-124, which is abundantly expressed in normal brain tissue but significantly downregulated in glioma cells, has been shown to target IQGAP1 and regulate downstream signaling to inhibit glioma cell migration and invasion (92).Additionally, the traditional Chinese medicine compound shikonin has been found to reduce IQGAP1 expression and mTOR phosphorylation, potentially modulating the mTOR/Akt pathway.