Supporting this observation was a decrease in TNF-a levels and Pseudomonadota alongside an increase in IL - 10 and Bacteroidota. These bacterial-induced changes inhibited LPS production by the gut microbiota, partially “reversing” inflammation through induced immunomodulation (114).These findings suggest a novel and effective approach for treating endometriosis or at least reducing its symptoms by targeting microbiome restoration. The gene discussed is TNF; the disease is endometriosis.