PPARG and hepatocellular carcinoma: Treatment with exosomes derived from FABP5-knockout (FABP5-KO) HCC cells significantly downregulated the expression of key PPARγ target genes related to lipid uptake and storage, including SCD1, FASN, and SREBF1, suggesting that FABP5 promotes lipid accumulation via activation of the PPARγ pathway (Figure 6A).