Its expression is significantly upregulated in various cancers, including HCC, where it is associated with malignant tumor progression and poor patient prognosis (18).Extensive research has established intracellular FABP5 as a multifunctional oncoprotein that drives tumor proliferation, invasion, and metastasis through facilitating fatty acid uptake/utilization, inducing chemoresistance pathways, and modulating cancer cell-intrinsic inflammatory signaling, among other mechanisms (19–22). This evidence concerns the gene FABP5 and hepatocellular carcinoma.