To investigate the effects of 225Ac-anti-CCR8 RIT on the tumor growth as well as on the numbers of CCR8+ ti-Tregs, we performed RIT of CT26 (Figures 2A, B) and MC38 (Figures 2C, D) tumor bearing mice with 225Ac-anti-CCR8 mAb. Here, CCR8 is linked to neoplasm.