ACSL4 and neoplasm: Notably, Lysophosphatidylcholine Acyltransferase 3 (LPCAT3) and LOX are respectively involved in the incorporation of arachidonic acid into membrane phospholipids and the oxidation of these phospholipids, collectively promoting ACSL4-dependent tumor ferroptosis induced by IFN-γ and arachidonic acid (78).