P2RX7 and neoplasm: When tumor cells undergo ferroptosis, they release damage-associated molecular patterns (DAMPs) such as high mobility group box 1 (HMGB1), adenosine triphosphate (ATP), and KRASG12D, which engage pattern recognition receptors (e.g., toll-like receptor 4,TLR4; P2X Ligand-Gated Ion Channel 7,P2X7) on innate immune cells to trigger immunogenic cell death (ICD) or modulate polarization states (e.g., STAT3-driven M2 macrophage skewing via AGER/RAGE) (28–32).