XPC and female reproductive system neoplasm: Our case aligns with the findings of Yurchenko et al. (2023), who described a series of early-onset gynecological tumors, including a JGCT, in XP adolescents, highlighting the likely role of NER deficiency in ovarian tumorigenesis [11]. Moreover, international cohort analyses have shown that gynecological tumors account for 13% of internal malignancies in XP patients, with a particularly high risk among carriers of the delTG mutation in the XPC gene, warranting regular gynecological screening from adolescence onward [8].