Simultaneously, activated caspase‐1 processes pro‐IL‐1β into Cleaved‐IL‐1β, which can be secreted through the N‐GSDMD pore, further amplifies inflammation and induces pyroptosis.[15] Studies indicate that urate salts can activate the NLRP3 inflammasome linking hyperuricemia to pyroptosis.[16]. The gene discussed is NLRP3; the disease is hyperuricemia.