These findings suggest that curcumin inhibits the levels of NEK7 and the release of Cleaved‐IL‐1β, as well as the activation of CASPASE1 and GSDMD, thereby suppressing pyroptosis in the hyperuricemia and gout inflammation via the ROS/NEK7‐NLRP3 pathway. Here, NLRP3 is linked to hyperuricemia.