However, FAPα exhibits significant overexpression in keloids,[23] which commonly arise following cutaneous injuries, including burns, surgical procedures, and piercings.[24] Given that keloids may generate “false‐positive signals” in physiological contexts, the use of single‐locked probes designed for FAPα recognition poses a heightened risk of misdiagnosis during cSCC diagnosis. Here, FAP is linked to skin squamous cell carcinoma.