14-3-3θ interacts with several proteins implicated in PD, including αsyn, LRRK2 and parkin (Kawamoto et al., 2002; Berg et al., 2003; Dzamko et al., 2010; Nichols et al., 2010; Li et al., 2011; Sato et al., 2006), and loss of the ability of 14-3-3θ to regulate and interact with binding partners may promote the neurodegenerative process. This evidence concerns the gene LRRK2 and Parkinson disease.