LRRK2 and Parkinson disease: Because 14-3-3θ has been shown to interact with several proteins implicated in PD, including αsyn and LRRK2 (Berg et al., 2003; Dzamko et al., 2010; Kawamoto et al., 2002; Li et al., 2011; Nichols et al., 2010), phosphorylation of 14-3-3θ may impact toxicities related to these proteins.