Nominally, we observed a trend toward a stronger negative effect of APOE ε4 on episodic memory in NHB versus NHW (interaction β = 0.13; 95% CI: –0.01 to 0.27; unadjusted p = 0.07), and the diabetes × Hispanic interaction hinted at slightly better memory among Hispanics with diabetes (β = 0.16; 95% CI: 0.01 to 0.32; unadjusted p = 0.04), but neither survived adjustment (adjusted p > 0.90). This evidence concerns the gene APOE and diabetes mellitus.