Cell–cell communication analysis has revealed differences among CD8 + T cell subsets between ICB responders and non-responders, with Myxovirus resistance 1 (MX1)-high CD8 + T cells and circulating CD8 + T cells playing more significant roles in communication in responders, elucidating the functions and mechanisms of T cells in the ccRCC immune microenvironment [328]. The gene discussed is CD8A; the disease is nonpapillary renal cell carcinoma.