Multi-omics studies have identified cell type-specific TFs, such as zinc finger E—box—binding homeobox (ZEB1) in MCs, spleen—focus—forming virus (SFFV) proviral integration oncogene spi—C (SPIC) in B cells, eomesodermin (EOMES) in NK cells, ETS variant transcription factor 4 (ETV4) in non-tumor cells, E—twenty—six (ETS) transcription factor 1 (ETS1) in T cells, early B—cell factor 2 (EBF2) in cancer-associated fibroblasts (CAFs), and SRY—related HMG—box 8 (SOX8) in ECs. The gene discussed is EBF2; the disease is cancer.