SNAI2 and neoplasm: In contrast, the Metastasis-II program, which includes some ECM genes, lacks the expression of key EMT TFs like snail family transcriptional repressor (SNAIL), snail family transcriptional repressor 2 (SLUG), and twist basic helix-loop-helix transcription factor (TWIST), and shows a subtle shift in epithelial gene expression without a global change in epithelial markers, suggesting a distinct, non-canonical EMT process that may play a unique role in tumor metastasis [155].