In nccRCC, which includes subtypes such as pRCC, chrRCC, CDRCC, and sarcomatoid RCC (sarRCC), a study by Chen et al. utilizing scRNA-seq revealed that CD8 + T cells in nccRCC tumors exhibit an exhausted state, similar to ccRCC. The gene discussed is CD8A; the disease is nonpapillary renal cell carcinoma.