Three subgroups [serine proteinase inhibitor clade E member 2(SERPINE2) +, CCL23 +, and sclerostin (SOST) +] mainly originate from normal tissue, while subgroups 6 (ACKR1 +) and 1 [potassium voltage—gated channel subfamily E regulatory subunit 3 (KCNE3) +] are enriched in tumor tissue. The gene discussed is SOST; the disease is neoplasm.