In ICB responders with low high human leukocyte antigen (HLA) peptide binding affinity, pre-exhausted CD8 + T cells interact with pro-inflammatory tumor-associated macrophages (TAMs) and paired box gene 8 (PAX8) + MCs, while exhausted CD8 + T cells interact more with pre-exhausted CD8 + T cells, ECs, and MCs. This evidence concerns the gene CD8A and neoplasm.