The enhancer region of vascular endothelial growth factor A (VEGFA) also shows increased accessibility, while genes like egl-9 family hypoxia-inducible factor 3 (EGLN3) exhibit cancer-type-specific changes in chromatin accessibility, correlating with ccRCC pathological features and suggesting a role in its development. This evidence concerns the gene VEGFA and nonpapillary renal cell carcinoma.