However, scRNA-seq analysis of tumors from RCC pancreatic metastasis (RCCpm) revealed an intriguing finding: CD8 + T cells in RCCpm exhibit an active cytotoxic state, expressing GZMK [320], which contradicts the conventional understanding that CD8 + T cells in metastatic tissues are often exhausted [225]. The gene discussed is CD8A; the disease is metastasis.