Similarly, analysis of multi-regional scRNA-seq data in ccRCC has also categorized CD4 + T cells into multiple subsets, including CD4 + effector, CD4 + proliferating, and CD4 + activated immediate early gene (IEG) T cells, extending beyond CD4 + naive T cells and CD4 + Tregs [329]. Here, CD4 is linked to nonpapillary renal cell carcinoma.