Because ANGPT2 regulates angiogenesis through TEK and integrin signaling [78], and promotes neuroprotection in a model of ischemic stroke [79], the ANGPT2–TEK/ITGA5:ITGB1 signaling axis from EC:Exc3/Exc5 to fibroblasts (EC:Fib) likely represents a resilience-linked angiogenic support mechanism. This evidence concerns the gene ITGA5 and ischemic stroke.