KLF4, a pro-inflammatory transcription factor in glial cells, exhibited an opposing expression pattern in AD and resilience (ADvsRES Log2FC = 0.36, adj-P = 0.035; RESvsCTRL Log2FC = -0.56, adj-P = 0.038), suggesting resilience-specific downregulation of KLF4, likely related to suppression of neuroinflammation [64]. The gene discussed is KLF4; the disease is Alzheimer disease.