To investigate the role of the GAS6-TYRO3 axis in mediating crosstalk between TEAD3 + melanoma cells and macrophages, we isolated TEAD3 + high-risk tumor cells from melanoma-bearing mice and established five experimental groups: [1] PBS-treated control [2], co-culture with GAS6- macrophages [3], co-culture with GAS6 + macrophages [4], treatment with GAS6 alone, and [5] co-culture with GAS6 + macrophages in the presence of the TYRO3 inhibitor BMS-777,607. The gene discussed is TEAD3; the disease is melanoma.