Our observation of glucose intolerance in the absence of altered insulin sensitivity suggests that one or both of the following may have occurred in our thymectomized mice: 1) That liver and/or the pgWAT, but not the skeletal muscle was insulin resistant, but the ITT was not sensitive enough to detect these differences in insulin sensitivity (i.e. only 10–20% insulin-stimulated glucose uptake in liver and adipose, 80% in skeletal muscle [50]). This evidence concerns the gene INS and Glucose intolerance.