Although the prognostic gene expression of CHGB, FABP4, PLIN4, PLIN1, RPRM, C7, AQP8, C2CD4A, APLP1, ADH1B, and CD36 shows potential in predicting CRC prognosis, further research is needed to elucidate the regulatory mechanisms underlying the prognostic risk model. Here, PLIN4 is linked to colorectal carcinoma.