We identified 11 prognostic genes (CHGB, FABP4, PLIN4, PLIN1, RPRM, C7, AQP8, C2CD4A, APLP1, ADH1B, and CD36) and developed a CRC risk model that showed significant survival differences in the TCGA-CRC cohort and GSE17537, with AUCs over 0.6 at 3, 5, and 7 years. The gene discussed is AQP8; the disease is colorectal carcinoma.