Significantly higher gene expression levels of the S100A8/9 heterodimer: S100A8: 6.36-fold increase (LFC = 2.67 ± 0.41p = 0.002, 95% CI = 1.08 to 4.26); S100A9: 9.75-fold increase (mean LFC = 3.29 ± 0.40, p = 0.0005, 95% CI = 1.65 to 4.93), which are commonly associated with neutrophils and monocytes were also observed in high-grade glioma specimens. The gene discussed is S100A9; the disease is central nervous system cancer.