General inflammatory immune cell markers, CD45 (LFC = 3.37  ±  0.22, p < 0.0001, 95% CI = 2.78 to 3.96) and NLRP3 (LFC = 1.52  ±  0.21,, p < 0.0001, 95% CI = 0.95 to 2.11) were also significantly upregulated in glioma samples. Here, NLRP3 is linked to central nervous system cancer.