BRCA1 and ovarian cancer: When analyzing the TCGA ovarian cancer dataset we observed that ENSG00000272172.1 was overexpressed in BRCA1 and BRCA2 mutated tumors as well as tumors with BRCA1 hypermethylation, indicating that an overexpression of ENSG00000272172.1 can be the result of different HR-deficiency mechanisms (Fig. 4f)43.