As a pivotal regulator of immune function, MAP4K3 overexpression in T cells promotes IL-17A production and excessive T cell activation, driving autoimmune inflammatory disorders such as systemic lupus erythematosus (SLE), a chronic autoimmune condition affecting multiple organ systems, including the skin, kidneys and central nervous system75. The gene discussed is MAP4K3; the disease is systemic lupus erythematosus.