Supporting this, a study by Ho et al. investigated the tumorigenic effects of MAP4K3 in hepatocellular carcinoma (HCC) and demonstrated that increased MAP4K3 expression enhances IκB kinase (IKK) phosphorylation and promotes nuclear translocation of p65, thereby activating NF-κB signaling42. This evidence concerns the gene MAP4K3 and hepatocellular carcinoma.