YAP1 and atrial fibrillation: In addition, Wang et al. found that applying a 5% cyclic tensile strain reduced inflammation and encouraged the growth of AF cells by preventing YAP phosphorylation and NF-κB nuclear localization, while the application of 12% cyclic tensile strain notably induced a proinflammatory response by turning off YAP activity and turning on NF-κB signaling172.