In conclusion, Piezo1 in endothelium contributes to the formation of portal hypertensive ascites via the NF-ĸB−AQP1 pathway in liver cirrhosis, which indicates that blockage of the Piezo1−NFĸB−AQP1 pathway may be a useful strategy for the management of ascites in liver cirrhosis. This evidence concerns the gene PIEZO1 and Ascites.