For example, upregulation in males but downregulation in females (Table 4) are DEGs associated with sex determination/sex hormone (Znrf3/Phb2), body mass/T2D (Fto), immunity (Nlrc3), T cells (Trbv13-2), thyroid hormone (Thrap3), lipid metabolism (Ptdss1/Lpcat3), autophagy/proteasome (Becn1/Rnf111/Rnf144b), vesicle transport/endoplasmatic reticulum (Copb1/Osbpl2/Stx16) and transcription/replication (Ankrd17/Eif4h/Tfcp2). The gene discussed is RNF111; the disease is type 2 diabetes mellitus.