As TAK1 was shown to be a regulator of cell death after TRAIL stimulation in cancer cells through a dependent cIAP downregulation mechanism (Morioka et al, 2009a), the same team described TAK1 as a significant factor of cell fate decision after death receptor activation, by enabling a switch between apoptosis and necroptosis (Morioka et al, 2014). The gene discussed is TNFSF10; the disease is cancer.