Taken together, these results classify RAC1P29S as a constitutively active, gain-of-function mutant and an oncogene (Box 1) that transduces upstream signals to effectors such as IQGAP1, thereby promoting melanoma progression through enhanced proliferation, invasion, and epithelial-to-mesenchymal transition [53, 54]. Here, IQGAP1 is linked to melanoma.