Given our identification of marked CXCL10 and CXCL11 secretion from SOX17-silenced HPAECs together with elevated plasma CXCL10 in SOX17-PAH patients, it is plausible that these chemokines may feature as mediators of pulmonary vascular remodeling in SOX17-PAH. The gene discussed is SOX17; the disease is pulmonary arterial hypertension.