Subsequently, they treated diseased mice with various interventions: hPLP175–192/DR4-IE nanoparticles (as a positive control), uncoated nanoparticles (as a negative control), EAE-relevant hMOG97–108/DR4-IE nanoparticles (presenting a peptide distinct from the one used to induce the disease), or mCII259–273/DR4-IE nanoparticles (relevant to collagen-induced arthritis). Here, TNFRSF10A is linked to arthritic joint disease.