CD4 and myeloid sarcoma: These mice not only develop EAE symptoms after active immunization but also exhibit spontaneous neurological dysfunction.233–235 For example, it has been widely demonstrated that not all CD4+ T cells that recognize self-antigens are deleted in the central tolerance process that takes place in the thymus; therefore, autoreactive CD4+ T cells are present in the circulation in patients with MS, as well as in healthy controls.