The results indicated that reduced MBP-reactive T cells were correlated with delayed MS progression in both RRMS and SPMS patients.507,508 Another trial with four SPMS patients used myelin-reactive T-cell lines and revealed that two patients maintained a stable EDSS score, one patient demonstrated an improvement of one EDSS step, and the remaining patient experienced progression in the EDSS score. Here, MBP is linked to myeloid sarcoma.