Cathepsin L (CtsL, encoded by Ctsl) is a lysosomal and cytoplasmic protease that is participated in diverse cellular processes, especially as a potential marker for liver fibrosis.26 Expression of both the Ctsl gene and its corresponding protein CtsL was validated in CD11C+ and CD206+ macrophages with or without sialin OE. The gene discussed is CTSL; the disease is Hepatic fibrosis.