ADAMTS17 and Weill-Marchesani syndrome: The fact that mutations in ADAMTS10 and ADAMTS17 each cause WMS suggests that these genes cooperate, have superimposed mechanisms, or act in the same pathways that regulate the development or homeostasis of affected tissues, including the growth plate, which drives bone growth, the skin, and the eye (Hubmacher & Apte, 2011; Karoulias et al, 2020b).