FBN1 and Weill-Marchesani syndrome: Skin thickening is a feature of WMS syndrome, and decreased skin elasticity in Adamts10 KO and Adamts17 KO mice as well as increased skin thickness in Adamts10 WMS knock-in mice were reported previously (Mularczyk et al, 2018; Oichi et al, 2019; Wang et al, 2019).