It is worth mentioning that opposite muscle phenotypes have been observed in patients with mutations in the same gene, notably in FBN1, where some mutations cause WMS, featuring a (pseudo)muscular built, whereas most FBN1 mutations cause Marfan syndrome, which is characterized by low muscle mass (Sakai & Keene, 2019). This evidence concerns the gene FBN1 and Weill-Marchesani syndrome.