Recent evidence suggests that loss of function of the complex components is associated with neurological diseases, including amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis [91], Charcot-Marie-Tooth disorder [90] [loss of Fig4] and paediatric neurological disorders [92] [loss of Vac14], while PIKfyve inhibition has been suggested to prevent ALS pathology [93], Alzheimer’s [94] and Parkinson’s Disease [95]. Here, VAC14 is linked to amyotrophic lateral sclerosis.