In addition, Ins(1,4,5,6)P4 binds to the PH domain to 130 kDa protein (p130) [365,366], RAC-protein kinase and diacylglycerol kinase [366], and is induced by angiotensin-II and cyclic AMP in adrenal glomerulosa cells [367], by endothelin-1 in rat fibroblasts [368] and through stimulation of the T-cell receptor in human T-lymphocytes [369], with future research required to understand if Ins(1,4,5,6)P4 has indeed a role in cancer and immune cell biology. The gene discussed is AKT1; the disease is cancer.