CDIPT and metabolic dysfunction-associated steatotic liver disease: Furthermore, a genetic screen for liver defects in zebrafish showed that a lack of de novo PI synthesis through CDIPT (i.e. phosphatidylinositol synthase (PIS)) was associated with increased hepatic ER stress and a MASLD-like phenotype in zebrafish [493], overall pointing to hepatic PI (or PI metabolites) being protective in MASLD pathogenesis.