PIK3CA and metabolic dysfunction-associated steatotic liver disease: In the previous sections, we have the discussed the role of various phosphoinositides and IPs in the regulation of PI3K/Akt signalling, the generation of insulin-mimicking inositol phosphoglycans and glycosylphosphatidylinositol (GPI) anchors on proteins, as well as the direct impact of myo- and/or chiro-inositol on AMPK activity and mitochondrial function, pointing to an important role of IP metabolism in MASLD and hepatic insulin sensitivity.