ABCA1 and metabolic dysfunction-associated steatohepatitis: Given that cholesterol homeostasis plays an important role in the pathogenesis of MASLD, and ABCA1 expression has been shown to be significantly decreased in patients with MASH and liver fibrosis [524], this points to an important (and potentially underappreciated) role for nuclear PIP2 in cholesterol efflux and MASH pathogenesis.