CSRP3 and hydrops fetalis: By 6 and 10 weeks, Holmes et al. MLPKO29 showed significant systolic function (LV FS% 22 vs. 39; 16 vs. 36%) and LV dilation (3.8 vs. 3.4; 4.2 vs. 3.4 mm) vs. MLP+/+, and the up-regulation of these pathways became more severe, along with the two other typical HF alterations: down-regulation of fatty acid oxidation and up-regulation of apoptosis.