MLPKO-RADfl/fl and MYH6-MerCreMer-MLPKO-RADfl/fl mice progressed to a DCM phenotype at 2.5-months, and then all mice were administered tamoxifen to induce cardiomyocyte-restricted RAD deletion in the latter (cRADΔ/Δ; Figure 1A). The gene discussed is MYH6; the disease is familial dilated cardiomyopathy.