In this vein, downstream excitation-transcription effectors’ (e.g. GATA4 and CREB) target genes’ expression were attenuated in cRADΔ/Δ, notably TNNT2, NPPA, NPPB, ACTA1, LRRC10, and MYH7 are among transcripts down-regulated by RAD knockout intervention of DCM. This evidence concerns the gene GATA4 and familial dilated cardiomyopathy.