Subsequent studies reported improvements in sit and reach flexibility (+ 33%), total (-16 mg.dL− 1) and low-density lipoprotein (LDL) cholesterol (-18 mg.dL− 1), insulin concentration (-7 μIU.mL− 1) and decreased homeostatic model assessment for insulin resistance (HOMA-IR: -2.6 A.U). The gene discussed is INS; the disease is Insulin resistance.