In IFN-γ-treated MDA-MB-231 breast cancer cells, its absence leads to the down-regulation of three proteins – cell adhesion molecule 1 (CADM1), scavenger receptor class F member 2 (SCARF2) and syntaxin binding protein 6 (STXBP6) – whilst up-regulating the expression of one, glutathione hydrolase 5 proenzyme (GGT5), but sequence alignment has not revealed any shared features among these proteins [127]. The gene discussed is GGT5; the disease is breast carcinoma.