We also confirmed that kidneys of the genetic LOF SP model were protected from HFD similar to studies performed with pharmacologic SGLT2 inhibitors (18) and that gene pathways altered in PTCs and kidneys of WT mice fed HFD were similar to those observed in patients and mice with both DKD and CKD (10, 12, 14, 36, 37). The gene discussed is SLC5A2; the disease is chronic kidney disease.