MAT2A and metabolic syndrome: Administration of LD MAT2Ai abolished differences between WTHFD mice and SPHFD groups with respect to kidney function and histology (Figure 5, F and G), supporting a model whereby decreased levels of Mat2a in PTCs of WTHFD mice are important in progression of injury and play a causal role in tubular injury in metabolic syndrome, while preservation of Mat2a levels in PTCs of SPHFD mice is protective.