By ROC analysis the top 10 proteins differentiating patients with LN with high CI from those without were BGH3, ROBO2, MSP, C3adesArg, prekallikrein, C5, C5b6 complex, ECM1, HRG, and iC3b, in order of descending AUC values with the minimal AUC value being 0.90 (Figure 6B). The gene discussed is C5; the disease is lobular neoplasia.