ESR1 and neoplasm: We did not find any significant differences in the ER status (χ2 = 0.90, p = 0.34), PR status (χ2 = 0.56, p = 0.45), tumor grade (χ2 = 0.32, p = 0.57), intracranial location (χ2 = 1.50, p = 0.83), or contrast agent (χ2 = 0.56, p = 0.45) between the HER2‐positive and HER2‐negative lesions.