To test this hypothesis, we generated bone marrow chimeric mice that are deficient in DNase1 and DNase1L3 in all cells of hematopoietic origin by adoptively transferring bone marrow cells obtained from Dnase1−/−Dnase1l3−/− mice into lethally irradiated atherosclerosis-prone Ldlr−/− mice (hematopoietic cell–specific DNase1/DNase1L3 knockout [DNase-HCKO]). Here, DNASE1L3 is linked to atherosclerosis.