TRPM3 and Hypertension: In addition, like Trpm3-KO mice, BPN mice showed no significant elevation in BP in response to AngII.19 These results indicate that both Trpm3-KO mice and mice with low renal expression of TRPM3 channels share a common phenotype of protection against AngII-induced hypertension, pointing toward a role of renal TRPM3 in BP regulation.