Interestingly, both Trpm3-KO and BPN mice19 exhibit significant protection against AngII-dependent hypertension, as described previously for kidney proximal tube selective At1r-KO.35 Thus, although the evidence remains indirect, these observations highlight a potential role for TRPM3 in modulating renal RAAS responses and contributing to systemic BP regulation. This evidence concerns the gene AGTR1 and hypertensive disorder.