TRPM3 and Hypertension: Elimination of this pathway reduces proximal fluid reabsorption and alters expression of key Na+ transporters, modifying pressure-natriuresis and providing substantial protection against hypertension.38 Interestingly, proximal tubule-KO mice also exhibit changes in the expression and function of transporters in downstream nephron segments,39 which can be related to the mechanisms involved in the effects of TRPM3 channels, as they are not expressed in the proximal tubule (Figure 5).