Additionally, several metabolic proteins are reduced in content and/or activity with AD brains and correlate with greater Aβ deposits, such as impairments in insulin‐driven Akt/mammalian target of rapamycin (mTOR) complex 1 (mTORC1) signaling10, 11 and reductions in the enzyme activity of the major Kreb‐cycle enzymes, α‐ketoglutarate‐dehydrogenase and pyruvate dehydrogenase.12 The gene discussed is INS; the disease is Alzheimer disease.