Specifically, in the PFC of humans with AD, we demonstrate greater Akt S473 phosphorylation, greater content of OXPHOS complexes III and V paired with lower OCR through complex I and III, greater AMPA GluA1 and synaptophysin expression, greater anti‐inflammatory IL‐2 content, and lower expression of Iba1 in the gray matter of human AD individuals. Here, AIF1 is linked to Alzheimer disease.