CD8A and glioblastoma: Our data, together with previous observations describing the ability of indisulam in inducing a proinflammatory microenvironment and increasing CD8+ T cell infiltration,60,77 support the possibility of expanding the repertoire of therapeutically relevant HLA I-restricted neoepitopes, offering new avenues for low-TMB and antigenically heterogeneous tumors such as glioblastomas.