GSK3β is a serine/threonine kinase heavily implicated in tau hyperphosphorylation and other pathological processes in AD, whereas SIRT1 is an NAD+-dependent deacetylase that governs stress resistance, metabolic regulation, and protein homeostasis in neurons (Chauhan et al., 2022; Santos et al., 2023). Here, MAPT is linked to Alzheimer disease.