MAPT and Alzheimer disease: Alzheimer’s disease is a multifactorial neurodegenerative disorder characterized by progressive cognitive decline and hallmark brain lesions: extracellular amyloid-β (Aβ) plaques and intracellular neurofibrillary tangles (NFTs) of hyperphosphorylated tau (Jellinger, 2022; Kaur et al., 2021).