In STZ-induced diabetes rats, 6-week sinomenine treatment significantly ameliorated elevated blood glucose (GLU) levels and reduced urinary albumin excretion (UAE) values, meanwhile, further investigation revealed that its anti-DKD mechanism may play a protective role in the kidney by down-regulating the expression of IL-18/IL-1β in human glomerular endothelial cells (HrGECs) and renal tissues (Zhang and Wang, 2022). The gene discussed is ALB; the disease is diabetes mellitus.