In addition, tetrandrine effectively reduced malondialdehyde (MDA), lactate dehydrogenase (LDH), and ROS levels in STZ-induced DKD rats by activating the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling axis, while increasing SOD activity (Su et al., 2020). The gene discussed is HMOX1; the disease is diabetic kidney disease.