For example, gut microbiota can influence the concentration of bile acid and the level of interleukin-22 to orchestrate polycystic ovary syndrome (Qi et al., 2019), Akkermansia muciniphila can improves cognitive function in aged mice by reducing the proinflammatory cytokine IL - 6 (Zhu et al., 2023). Here, IL22 is linked to polycystic ovary syndrome.