NFKB1 and Sepsis: In addition, in the early stage of sepsis, the NF-κB signaling cascade, triggers the positive feedback release of pro-inflammatory factors such as IL - 1β, IL - 6, and PAF, and upregulates the secondary infiltration of neutrophils mediated by IL - 8, forming an “inflammation-coagulation vicious cycle”, which ultimately leads to intestinal barrier collapse and multiple organ dysfunction (Kurt et al., 2007; Sun et al., 2021; Wang et al., 2021).