To investigate CIN’s immunomodulatory mechanism, we analyzed Dectin-1 signaling components (Dectin-1, SYK, and CARD9), NF-κB activation, and proinflammatory cytokines (TNF-α and IL-1β) in RAW264.7 and PMA-differentiated THP-1 macrophages during a 24-h fungal infection. This evidence concerns the gene SYK and cervical squamous intraepithelial neoplasia.