Regarding the limitations of current GC diagnostic methods (such as gastroscopy and tumor marker detection) in terms of sensitivity and specificity, this study identified five ADME-related prognostic genes (UGT1A1, ADH4, ADH1B, CYP19A1, and GPX3) that exhibit unique expression patterns in tumor tissues (UGT1A1, ADH1B, CYP19A1, and GPX3 show significant downregulation). This evidence concerns the gene GPX3 and neoplasm.