MYH11 and neoplasm: Myofibroblasts are typically defined by high expression of MYH11 and low expression of RERGL. In multiple tumor models, fibroblasts exhibiting elevated MYH11 expression have been reported to play roles in immune regulation, promotion of tumor cell proliferation and migration, as well as inhibition of apoptosis(Grout et al., 2022; Lin et al., 2025).