The candidate potential mediators are chosen from known causal factors of NAFLD, including T2DM (HbA1c, fasting glucose, fasting insulin), obesity (BMI, body fat percentage, waist circumference, WHR), hypertension (diastolic blood pressure, systolic blood pressure), and dyslipidemia (TG, total cholesterol, HDL‐C, LDL‐C, VLDL‐C; concentration of VLDL, LDL, and HDL particles in different sizes; cholesterol to total lipids ratio in VLDL, LDL, and HDL particles in different sizes). The gene discussed is INS; the disease is obesity disorder.