Among these differentially expressed mRNAs, 10 mRNAs were identified as significant: CA1, CHP2, MMP1, CXCL8, HSD17B2, TSPAN7, MS4A12, SLC26A2, DHRS9, and HSD11B2, and we screened the highest expression RNA, namely, TSPAN7, to investigate their role in CRC. The gene discussed is HSD17B2; the disease is colorectal carcinoma.