PDHX and neuroblastoma: Studies have shown that in the CHP-212 neuroblastoma cell line, MYCN on ecDNA can hijack the enhancer element of the tribbles pseudokinase 2 (TRIB2) gene (16), CDX2 on ecDNA in COLO320-DM cells can hijack the MYC enhancer (74), and in SNU16 cells, MYC, FGFR2, CD44, and pyruvate dehydrogenase complex component X (PDHX) on ecDNA can mutually hijack enhancers (74).