Mitochondrial polygenic scores (MGS) may be associated with PD but require validation across diverse populations.<h4>Objective</h4>To validate the association between the MGS, PD status and age-at-onset (AAO) in idiopathic and <i>LRRK2-</i> PD across various ancestries.<h4>Methods</h4>We analyzed data from 17,129 PD patients and 13,872 healthy individuals across 10 ancestries within the Global Parkinson's Disease Genetic Program. The gene discussed is LRRK2; the disease is Parkinson disease.